硫糖铝混悬液治疗复发性阿弗他口炎
Sucralfate suspension as a treatment of recurrent aphthous stomatitis.
作者信息
Rattan J, Schneider M, Arber N, Gorsky M, Dayan D
机构信息
Department of Gastroenterology, Tel Aviv Medical Centre, Sackler School of Medicine, Israel.
出版信息
J Intern Med. 1994 Sep;236(3):341-3. doi: 10.1111/j.1365-2796.1994.tb00805.x.
DESIGN
A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial.
SETTING
A university hospital.
SUBJECTS
Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups.
INTERVENTION
In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years.
RESULTS
After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission.
CONCLUSION
Sucralfate suspension should be added to the armament of treatment modalities of RAS.
设计
一项前瞻性随机、双盲、安慰剂对照、交叉临床试验。
地点
一家大学医院。
研究对象
招募了21例症状性复发性阿弗他口炎（RAS）患者，这些患者对传统治疗无反应。他们被分为三组。
干预措施
在一项交叉试验中，患者接受了2年的硫糖铝口服混悬液、抗酸溶液或安慰剂治疗。
结果
经过2年的随访，发现硫糖铝在疼痛持续时间、愈合期缩短、首次治疗反应时间和缓解期持续时间方面均优于安慰剂和抗酸剂（P < 0.001）。
结论
硫糖铝混悬液应添加到RAS的治疗方法中。
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