Morecroft J A, Spitz L, Hamilton P A, Holmes S J
Department of Surgery, Institute of Child Health, London, England.
J Pediatr Surg. 1994 Jun;29(6):798-800. doi: 10.1016/0022-3468(94)90374-3.
Plasma tumour necrosis factor (TNF) and interleukin-6 (IL-6) levels of 18 infants with necrotizing enterocolitis (NEC) were measured at the time of diagnosis or on transfer to a paediatric surgical unit. Whereas TNF levels were similar for infants managed medically (stage II, n = 8) and surgically (stage III, n = 7), IL-6 levels were significantly higher in stage III cases (mean, 3,127 pg/mL [95% CI, 1,809 to 4,445 pg/mL]) than in stage II (mean, 127 pg/mL [95% CI, 10 to 329 pg/mL]; P = .001). Neither TNF nor IL-6 level predicted eventual outcome. Plasma IL-6 may be useful as an indication for operation in NEC.
在诊断时或转至小儿外科病房时，对18例坏死性小肠结肠炎（NEC）婴儿的血浆肿瘤坏死因子（TNF）和白细胞介素-6（IL-6）水平进行了测量。接受保守治疗的婴儿（II期，n = 8）和接受手术治疗的婴儿（III期，n = 7）的TNF水平相似，而III期病例的IL-6水平（平均3127 pg/mL [95% CI，1809至4445 pg/mL]）显著高于II期（平均127 pg/mL [95% CI，10至329 pg/mL]；P = 0.001）。TNF和IL-6水平均不能预测最终结局。血浆IL-6可能有助于作为NEC手术的指征。
