Soutani M
Department of Physiology, School of Medicine, Ehime University, Japan.
Nihon Seirigaku Zasshi. 1994;56(6):181-95.
Erythrocyte flow dynamics in microvessels was quantitatively observed with an isolated rabbit mesentery. The flow resistance in the microvascular bed was analyzed with respect to the thickness of a cell-free layer along the inner vessel wall and the suspension viscosity of erythrocytes (in terms of hematocrit and erythrocyte deformability). The thickness of cell-free layer increased with the increase in the inner diameter of microvessels, by lowering the hematocrit, and by increasing the erythrocyte velocity, but it was constant in capillary region. The thickness decreased by decreasing the erythrocyte deformability with diamide, while it increased by accelerating the erythrocyte aggregation with dextran. The flow resistance in the microvascular bed was not simply related to the thickness of a cell-free layer, but it was well correlated to the viscosity of erythrocyte suspension. In the flow pattern of erythrocytes, the maximum inner diameter of microvessel required to induce parachute-like deformation decreased by decreasing the erythrocyte deformability. Moreover, the flow of erythrocytes became inhomogeneous and intermittent by accelerating the erythrocyte aggregation.
用离体兔肠系膜定量观察微血管内红细胞的流动动力学。根据沿血管内壁无细胞层的厚度和红细胞的悬浮粘度（以血细胞比容和红细胞变形性表示）分析微血管床的流动阻力。无细胞层的厚度随着微血管内径的增加、血细胞比容的降低和红细胞速度的增加而增加，但在毛细血管区域是恒定的。用二酰胺降低红细胞变形性时厚度减小，而用右旋糖酐加速红细胞聚集时厚度增加。微血管床的流动阻力并非简单地与无细胞层的厚度相关，而是与红细胞悬浮液的粘度密切相关。在红细胞的流动模式中，诱导降落伞样变形所需的微血管最大内径随着红细胞变形性的降低而减小。此外，通过加速红细胞聚集，红细胞的流动变得不均匀且间歇性。
