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[干扰素治疗慢性丙型肝炎——使用逻辑回归模型进行多变量分析评估干扰素治疗效果的预测因素]

[Interferon treatment of chronic hepatitis C--assessment of predictive factors to the effect of interferon treatment using multivariate analysis with the logistic regression model].

作者信息

Terada M, Ikegami F

机构信息

Department of Gastroenterology, Kanto-Teishin Hospital.

出版信息

Nihon Rinsho. 1994 Jul;52(7):1774-7.

PMID:8078201
Abstract

We treated 156 chronic hepatitis C patients with alpha-interferon (IFN) and assessed the response rate and the predictive factors to the effect of IFN treatment. Complete response (CR) rate was 39.1%, and CR with serum HCV-RNA disappearance rate was 29%. CR to IFN treatment was dependent on HCV serotype and serum HCV-RNA. Patients of serotype II and low serum HCV-RNA were effective to IFN treatment.

摘要

我们用α干扰素治疗了156例慢性丙型肝炎患者,并评估了对干扰素治疗效果的反应率和预测因素。完全缓解(CR)率为39.1%,血清HCV-RNA消失的CR率为29%。对干扰素治疗的CR取决于HCV血清型和血清HCV-RNA。II型血清型和低血清HCV-RNA的患者对干扰素治疗有效。

相似文献

1
[Interferon treatment of chronic hepatitis C--assessment of predictive factors to the effect of interferon treatment using multivariate analysis with the logistic regression model].[干扰素治疗慢性丙型肝炎——使用逻辑回归模型进行多变量分析评估干扰素治疗效果的预测因素]
Nihon Rinsho. 1994 Jul;52(7):1774-7.
2
[HCV-serotype and IFN response].[丙型肝炎病毒血清型与干扰素反应]
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Early loss of serum hepatitis C virus RNA can predict a sustained response to interferon therapy in patients with chronic hepatitis C.血清丙型肝炎病毒RNA早期消失可预测慢性丙型肝炎患者对干扰素治疗的持续应答。
Am J Gastroenterol. 1997 Jan;92(1):61-5.
4
Treatment of chronic hepatitis C with interferon-alpha. Clinical histological and virological implications.α-干扰素治疗慢性丙型肝炎。临床组织学及病毒学意义。
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Prospective comparison of four lymphoblastoid interferon alpha schedules for chronic hepatitis C. A multivariate analysis of factors predictive of sustained response to treatment.慢性丙型肝炎四种淋巴母细胞样α干扰素治疗方案的前瞻性比较。预测治疗持续应答因素的多变量分析。
Eur J Gastroenterol Hepatol. 1997 Dec;9(12):1169-77.
6
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.慢性丙型肝炎病毒1b感染患者非结构蛋白5A基因的突变与对干扰素的反应
N Engl J Med. 1996 Jan 11;334(2):77-81. doi: 10.1056/NEJM199601113340203.
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Efficacy of interferon alfa therapy in chronic hepatitis C patients depends primarily on hepatitis C virus RNA level.干扰素α治疗慢性丙型肝炎患者的疗效主要取决于丙型肝炎病毒RNA水平。
Hepatology. 1995 Nov;22(5):1351-4.
8
Parameters predicting response to alpha-interferon treatment in chronic hepatitis C.预测慢性丙型肝炎患者对α-干扰素治疗反应的参数。
Hepatogastroenterology. 1997 Mar-Apr;44(14):484-91.
9
A statistical analysis of predictive factors of response to human lymphoblastoid interferon in patients with chronic hepatitis C.慢性丙型肝炎患者对人淋巴母细胞干扰素反应的预测因素的统计分析。
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Hepatic iron stainings in chronic hepatitis C patients with low HCV RNA levels: a predictive marker for IFN therapy.丙型肝炎病毒(HCV)RNA水平较低的慢性丙型肝炎患者的肝脏铁染色:干扰素治疗的预测标志物
Am J Gastroenterol. 1997 Sep;92(9):1463-6.