Yamamoto M, Takahashi K, Ohyama M, Sasamata M, Yatsugi S, Okada M, Endoh H
Applied Pharmacology & Development Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 1994 May;18(3):603-13. doi: 10.1016/0278-5846(94)90016-7.
Effects of indeloxazine, a cerebral activator, on passive avoidance learning by disruption of cholinergic transmission were studied in rats. The shortened latency was prolonged when indeloxazine was administered before training in rats subjected to scopolamine-injection, ethylcholine aziridinium ion (AF64A)-treatment and nucleus basalis magnocellularis (NBM) lesion. Indeloxazine administered immediately after training also showed ameliorating effects on passive avoidance in NBM-lesioned rats. Indeloxazine increased extracellular acetylcholine concentration in the frontal cortex of rats. Indeloxazine possesses facilitatory effects on cerebral function in part due to activation of the central cholinergic system.
研究了脑激活剂茚达品通过干扰胆碱能传递对大鼠被动回避学习的影响。在接受东莨菪碱注射、氮丙啶离子乙胆碱（AF64A）处理和基底大细胞核（NBM）损伤的大鼠中，训练前给予茚达品可使缩短的潜伏期延长。训练后立即给予茚达品对NBM损伤大鼠的被动回避也有改善作用。茚达品可增加大鼠额叶皮质的细胞外乙酰胆碱浓度。茚达品对脑功能具有促进作用，部分原因是激活了中枢胆碱能系统。
