Bell H, Rostad B, Raknerud N, Try K
Medisinsk avdeling, Aker sykehus, Oslo.
Tidsskr Nor Laegeforen. 1994 Jun 10;114(15):1697-9.
Computed tomography (CT) was performed to estimate the density of the hepatic and splenic parenchyma in 18 patients with hemochromatosis. The mean CT density was 79 +/- 21 Hounsfield units compared with 61 +/- 9 (p < 0.01) in 31 controls without hepatic disease. Increased density above 79 Hounsfield units was found in eight patients out of 18 (44%). The highest density (125 Hounsfield units) was found in a patient with a serum ferritin of 6500 micrograms/l. There was an association between CT density and serum ferritin (r = 0.72, p < 0.01). The difference in density between liver and spleen gave better discrimination between patients and controls: 12 of 18 (67%) showed an increased difference in density between liver and spleen. We conclude that CT represents a non-invasive alternative to liver biopsy in cases where the latter is contraindicated. However, CT is not sensitive when serum ferritin is below 1,000 micrograms/l.
对18例血色素沉着症患者进行了计算机断层扫描（CT），以评估肝实质和脾实质的密度。18例血色素沉着症患者的平均CT密度为79±21亨氏单位，而31例无肝脏疾病的对照组平均CT密度为61±9（p<0.01）。18例患者中有8例（44%）的密度高于79亨氏单位。在一名血清铁蛋白为6500微克/升的患者中发现了最高密度（125亨氏单位）。CT密度与血清铁蛋白之间存在关联（r=0.72，p<0.01）。肝脏和脾脏之间的密度差异在区分患者和对照组方面表现更佳：18例中有12例（67%）肝脏和脾脏之间的密度差异增大。我们得出结论，在肝活检禁忌的情况下，CT是一种非侵入性的替代方法。然而，当血清铁蛋白低于1000微克/升时，CT并不敏感。
