Aĭsina R B, Zhitkova Iu V, Varfolomeev S D
Vopr Med Khim. 1994 May-Jun;40(3):31-5.
Affinity and fibrinolytic properties of streptokinase and two new preparations of acylated plasminogen-streptokinase activator complexes, produced by dissimilar procedures, were studied. Even after 1-min exposure, blood clot lysis carried out by the acyl activating complex was continued in blood plasma more than for 4 hrs, while the streptokinase produced blood clot lysis was accomplished within 1.5 hrs. After 1-min contact with clot in blood plasma the rates of lysis by streptokinase and these acylated plasminogen-streptokinase activator complexes types 1 and 2 constituted 23%, 37% and 63%, respectively, as compared with the rates detected during permanent contact of thrombolytics with blood clot. The activator properties of the thrombolytic agents itself and its stability in blood plasma were of importance even in similar affinity ability of free and acylated activating complexes.
研究了链激酶以及通过不同程序制备的两种新型酰化纤溶酶原-链激酶激活剂复合物的亲和力和纤溶特性。即使经过1分钟的暴露，酰化激活复合物在血浆中进行的血凝块溶解仍持续超过4小时，而链激酶产生的血凝块溶解在1.5小时内完成。与溶栓剂与血凝块持续接触期间检测到的速率相比，在血浆中与凝块接触1分钟后，链激酶以及1型和2型这些酰化纤溶酶原-链激酶激活剂复合物的溶解速率分别为23%、37%和63%。即使游离和酰化激活复合物具有相似的亲和力，溶栓剂本身的激活特性及其在血浆中的稳定性也很重要。
