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[自然杀伤细胞活性在慢性骨髓增殖性疾病发病机制中的作用]

[The role of natural killer cell activity in the pathogenesis of chronic myeloproliferative diseases].

作者信息

Guseva S A

出版信息

Lik Sprava. 1993 Jul(8):70-3.

PMID:8079482
Abstract

The study of natural killers' (NK) activity was carried out in 114 patients with myelo-proliferative diseases (MPD). Fall of NK-activity was found in all patients. Chronic myeloleukemia was associated with the most considerable decrease of blood leukocytes' cytotoxicity. Patents with gross tumorous mass and exacerbation of leukemic process revealed reduced NK activity as compared to those with low mass of tumor and stable leukemia.

摘要

对114例骨髓增殖性疾病（MPD）患者进行了自然杀伤细胞（NK）活性研究。发现所有患者的NK活性均下降。慢性粒细胞白血病与血液白细胞细胞毒性的最显著降低相关。与肿瘤肿块较小且白血病病情稳定的患者相比，有巨大肿瘤肿块且白血病病情加重的患者NK活性降低。

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