N-羟甲基去甲可替宁，可替宁一种新的体外主要代谢产物。

N-hydroxymethylnorcotinine, a new primary in vitro metabolite of cotinine.

Li Y, Gorrod J W

Chelsea Department of Pharmacy, King's College London, UK.

Xenobiotica. 1994 May;24(5):409-15. doi: 10.3109/00498259409043244.

Abstract

N-Hydroxymethylnorcotinine; 5-(3'-pyridyl)-1-hydroxymethyl-pyrrolidone-2, was found as a new primary metabolite of cotinine in vitro. 2. N-Hydroxymethylnorcotinine was synthesized and characterized by gas chromatography-mass spectrometry, mass spectra, nuclear magnetic resonance and ultraviolet spectroscopy. 3. This new metabolite is formed by incubation of cotinine with hamster hepatic microsomes in the presence of NADPH and oxygen.

摘要

N-羟甲基去甲可替宁；5-(3'-吡啶基)-1-羟甲基-吡咯烷酮-2，在体外被发现是可替宁的一种新的主要代谢产物。2. N-羟甲基去甲可替宁通过气相色谱-质谱联用、质谱、核磁共振和紫外光谱进行了合成与表征。3. 这种新的代谢产物是在烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和氧气存在的情况下，可替宁与仓鼠肝微粒体孵育形成的。