胚胎期兔血中血红蛋白与氧结合的高度协同性。

High cooperativity of hemoglobin-oxygen binding in embryonic rabbit blood.

作者信息

Holland R A, Calvert S J

机构信息

School of Physiology & Pharmacology, University of New South Wales, Kensington, Sydney, Australia.

出版信息

Adv Exp Med Biol. 1994;345:159-65. doi: 10.1007/978-1-4615-2468-7_21.

DOI:10.1007/978-1-4615-2468-7_21

PMID:8079703

Abstract

In rabbit embryos, 13 or 14 days after conception, the oxygen equilibrium curve climbs steeply above about 50% saturation. The value of the Hill coefficient (nH) in the upper part of the curve is significantly greater than 4, indicating aggregation of tetramers or interaction between adjacent tetramers. This is the first time this has been described in blood of a normal eutherian (placental) mammal.

摘要

在兔胚胎受孕13或14天后，氧平衡曲线在饱和度约50%以上急剧上升。曲线上部的希尔系数（nH）值显著大于4，表明四聚体聚集或相邻四聚体之间存在相互作用。这是首次在正常真兽亚纲（胎盘）哺乳动物的血液中描述到这种情况。