临床内分泌学家视角下的骨质疏松症

Osteoporosis from the point of view of the clinical endocrinologist.

作者信息

Szũcs J

机构信息

First Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Agents Actions. 1994 Mar;41(1-2):80-3. doi: 10.1007/BF01986398.

DOI:10.1007/BF01986398

PMID:8079825

Abstract

The physiology of the bone tissue is reviewed from the point of view of a clinical endocrinologist. The effect of the main calcium-regulating hormones and various local factors on the osteoblasts and osteoclasts is discussed. The aim of this review is to summarize the physiological and pathophysiological role of calcitonin, parathormone, vitamin D3, thyroid hormones, glucocorticoids, growth hormone and sex hormones on bone metabolism. The significance of endocrinological dysfunctions in the pathogenesis of osteoporosis, the most wide-spread metabolic bone disease, is emphasized. A theory concerning the pathogenetic role of androgen hormone deficiency in postmenopausal osteoporosis is discussed in detail.

摘要

本文从临床内分泌学家的角度对骨组织生理学进行了综述。讨论了主要钙调节激素和各种局部因素对成骨细胞和破骨细胞的影响。本综述的目的是总结降钙素、甲状旁腺激素、维生素D3、甲状腺激素、糖皮质激素、生长激素和性激素在骨代谢中的生理和病理生理作用。强调了内分泌功能障碍在最常见的代谢性骨病——骨质疏松症发病机制中的重要性。详细讨论了雄激素缺乏在绝经后骨质疏松症发病机制中的理论。