Rhodes R H, Cole M, Takaoka Y, Roessmann U, Cotes E E, Simon J
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Arch Pathol Lab Med. 1994 Sep;118(9):897-911.
Two cases of intraventricular neuroblastomas were compared with cases of intraventricular and hemispheric neuroblastomas that have been reported in the published literature. The following order of tumor subtypes was found in patients with increasing age: hemispheric neuroblastoma, intraventricular undifferentiated neuroblastoma, intraventricular differentiated neuroblastoma, and intraventricular neurocytoma; for patients with intraventricular neuroblastomas, this was also the order of increasing cellular maturation and survival. Neuronal morphologic or epitope differentiation was associated with a longer survival time than lack of differentiation by Kaplan-Meier product-limit estimates and with a better survival rate (chi 2) for intraventricular tumors but not for hemispheric tumors. Pathologic distinction of a neurocytoma was confirmed with immunostaining or ultrastructural studies that suggested that a neurocytoma is a matured neuroblastoma of a granule-cell (interneuron) phenotype. Differences among neuroblastoma groups bolster previous suggestions that intraventricular tumors arise differently than do cases of hemispheric tumors and follow a more benign course when neuronal differentiation is present.
将两例脑室内神经母细胞瘤与已发表文献中报道的脑室内和半球神经母细胞瘤病例进行了比较。在年龄递增的患者中发现了以下肿瘤亚型顺序：半球神经母细胞瘤、脑室内未分化神经母细胞瘤、脑室内分化型神经母细胞瘤和脑室内神经细胞瘤；对于脑室内神经母细胞瘤患者，这也是细胞成熟度增加和生存率提高的顺序。通过Kaplan-Meier乘积限估计，神经元形态或表位分化与较长的生存时间相关，对于脑室内肿瘤，其生存率更高（卡方检验），但对于半球肿瘤则不然。通过免疫染色或超微结构研究证实了神经细胞瘤的病理特征，提示神经细胞瘤是颗粒细胞（中间神经元）表型的成熟神经母细胞瘤。神经母细胞瘤组之间的差异支持了先前的观点，即脑室内肿瘤的发生方式与半球肿瘤不同，并且当存在神经元分化时，其病程更为良性。
