Leiderman D B, Albert P, Balish M, Bromfield E, Theodore W H
Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md.
Arch Neurol. 1994 Sep;51(9):932-6. doi: 10.1001/archneur.1994.00540210106019.
To examine the time course of alterations in glucose metabolism in relation to the interval from the last seizure, focus laterality, seizure frequency, and seizure type.
Metabolic study with the use of positron emission tomography with fludeoxyglucose F 18. Blinded scan evaluation with use of a standard template. Multivariate regression analysis of positron emission tomographic data.
National Institutes of Health Clinical Center, Bethesda, Md.
Thirty-two adults with intractable partial epilepsy and lateralized seizure onset documented by video-electroencephalographic monitoring.
Normalized metabolic rate for glucose ipsilateral and contralateral to the epileptic focus.
The most dramatic changes occurred in inferior temporal regions; the midtemporal region was affected as well. Effects lasting 48 hours were found after both simple and complex partial seizures. The time course was different for the two types of seizures. The inferior temporal metabolic rate ipsilateral to the focus increased compared with the interictal rate during the 24-hour period following simple partial seizures; a nadir occurred in the second 24 hours. The rate then rose to an intermediate level after 48 hours. The relative to an intermediate level after 48 hours. The relative regional increase in ipsilateral metabolism following complex partial seizures persisted for 48 hours before falling.
The brain may take longer than 24 hours after a partial seizure to return to its baseline state.
研究葡萄糖代谢改变的时间进程，及其与距上次发作的间隔时间、发作灶的侧别、发作频率和发作类型的关系。
采用氟脱氧葡萄糖F 18正电子发射断层扫描进行代谢研究。使用标准模板进行盲法扫描评估。对正电子发射断层扫描数据进行多变量回归分析。
马里兰州贝塞斯达的国立卫生研究院临床中心。
32名成年患者，经视频脑电图监测证实患有难治性部分性癫痫且发作起始部位局限。
癫痫灶同侧和对侧葡萄糖的标准化代谢率。
最显著的变化发生在颞叶下部区域，颞叶中部区域也受到影响。简单部分性发作和复杂部分性发作后均发现持续48小时的影响。两种发作类型的时间进程不同。简单部分性发作后的24小时内，癫痫灶同侧颞叶下部的代谢率相对于发作间期升高；在第二个24小时出现最低点。之后在48小时后升至中间水平。复杂部分性发作后同侧代谢的相对区域增加持续48小时后下降。
部分性发作后大脑可能需要超过24小时才能恢复到基线状态。
