Houbouyan L, Stoltz J F, Goguel A
Acta Haematol. 1975;53(5):300-8. doi: 10.1159/000208196.
The influence of penicillin G on the in vitro and in vivo ADP-induced platelet aggregation and on the platelet electrophoretic mobility has been studied. The in vitro investigations in presence of penicillin concentrations varying between 1,000 and 10,000 IU/ml of plasma, and doses of adenosine diphosphate (ADP) between 0.3 and 25/muM/ml, have shown that the photometric aggregation, as well as the screen filtration pressure are both decreased, according to the doses of antibiotic and ADP. The electrophoretic mobility is also impaired. The in vivo study of 8 patients submitted to massive penicillin therapy for bacterial endocarditis seems to be in agreement with the in vitro results, and has shown a prolonged bleeding time, an hypoadhesiveness, an impaired photometric aggregation with an early disa-gregation and a decrease of the screen filtration pressure and platelet electrophoretic mobility.
研究了青霉素G对体外和体内二磷酸腺苷（ADP）诱导的血小板聚集以及对血小板电泳迁移率的影响。在血浆中青霉素浓度介于1000至10000国际单位/毫升之间，二磷酸腺苷（ADP）剂量介于0.3至25微摩尔/毫升之间的体外研究表明，根据抗生素和ADP的剂量，光度法聚集以及筛滤压力均降低。电泳迁移率也受到损害。对8例因细菌性心内膜炎接受大剂量青霉素治疗的患者进行的体内研究结果似乎与体外研究结果一致，显示出血时间延长、低粘附性、光度法聚集受损伴早期解聚以及筛滤压力和血小板电泳迁移率降低。
