用于光动力疗法的吗啉代硫醇卟啉的评估。
Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
作者信息
Woodburn K W, Hill J S, Stylli S, Kaye A H, Reiss J A, Phillips D R
机构信息
Department of Biochemistry, La Trobe University, Bundoora, Australia.
出版信息
Br J Cancer. 1994 Sep;70(3):398-400. doi: 10.1038/bjc.1994.316.
Abstract
The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.
摘要
在脑胶质瘤动物模型中测量了一种源自血卟啉的吗啉硫醇卟啉的光坏死效力。给药剂量为20 mg kg-1，激光剂量从0至200 J cm-2不等。肿瘤坏死情况至少与血卟啉衍生物（HpD）的一样好，这种治疗反应可能归因于特定“光活性”亚细胞位点的靶向作用。
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