Kahn R S, Davidson M, Siever L J, Sevy S, Davis K L
Department of Psychiatry, Mount Sinai School of Medicine/Bronx Veterans Administration Hospital, New York, NY.
Biol Psychiatry. 1994 Jun 15;35(12):909-12. doi: 10.1016/0006-3223(94)91236-x.
The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.
研究了氯氮平治疗对血清素激动剂间氯苯哌嗪（mCPP）诱导的神经内分泌反应的影响。在9名精神分裂症住院患者中，经过2周的停药期后给予mCPP和安慰剂，在氯氮平治疗5周后再次给予。测量促肾上腺皮质激素（ACTH）、催乳素和mCPP水平。氯氮平治疗完全阻断了mCPP诱导的ACTH和催乳素释放，表明氯氮平阻断了介导这些激素反应的血清素受体。
