氯氮平治疗及其对血清素激动剂间氯苯哌嗪诱导的神经内分泌反应的影响。

Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine.

作者信息

Kahn R S, Davidson M, Siever L J, Sevy S, Davis K L

机构信息

Department of Psychiatry, Mount Sinai School of Medicine/Bronx Veterans Administration Hospital, New York, NY.

出版信息

Biol Psychiatry. 1994 Jun 15;35(12):909-12. doi: 10.1016/0006-3223(94)91236-x.

DOI:10.1016/0006-3223(94)91236-x

PMID:8080889

Abstract

The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.

摘要

研究了氯氮平治疗对血清素激动剂间氯苯哌嗪（mCPP）诱导的神经内分泌反应的影响。在9名精神分裂症住院患者中，经过2周的停药期后给予mCPP和安慰剂，在氯氮平治疗5周后再次给予。测量促肾上腺皮质激素（ACTH）、催乳素和mCPP水平。氯氮平治疗完全阻断了mCPP诱导的ACTH和催乳素释放，表明氯氮平阻断了介导这些激素反应的血清素受体。