Conceição I M, Goto S H, Frussa-Filho R
Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brasil.
Braz J Med Biol Res. 1994 Mar;27(3):731-5.
Four-month old male spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar EPM-1 (EPM-1) rats (14-15 animals per group) were tested in an elevated T maze to evaluate memory. Blood pressures of SHR were hyper at the time of experiment (200-235 mmHg). The elevated T maze used consisted of an open arm at right angles with two enclosed arms elevated 50 cm above the ground. Memory was quantified by the escape latency ratio (the ratio of the time it took for the rat to move from the open arm to one of the enclosed arms in the second session to that in the first session) and by the inhibitory avoidance latency (time from being placed at the end of an enclosed arm to move to the open arm, in a 3rd session). No significant differences in escape latency ratios were observed among SHR, WKY and EPM-1 rats. Conversely, SHR presented a significant reduction in inhibitory avoidance latency as compared to those of WKY and EPM-1 rats (mean +/- SEM latency: 65.9 +/- 18.4 s for SHR, 129.9 +/- 21.8 s for WKY animals and 181.2 +/- 11.2 s for EPM-1 rats). These data were discussed in light of the known lowered reaction to aversive environments exhibited by SHR, as compared to WKY and EPM-1 rats.
对4个月大的雄性自发性高血压大鼠（SHR）、Wistar-Kyoto大鼠（WKY）和Wistar EPM-1大鼠（每组14 - 15只动物）在高架T型迷宫中进行测试以评估记忆力。实验时SHR的血压偏高（200 - 235 mmHg）。所使用的高架T型迷宫由一条与两条封闭臂成直角的开放臂组成，封闭臂高出地面50厘米。记忆力通过逃避潜伏期比率（大鼠在第二阶段从开放臂移动到其中一条封闭臂所用时间与第一阶段所用时间的比率）和抑制性回避潜伏期（在第三阶段从被放置在封闭臂末端到移动到开放臂的时间）来量化。在SHR、WKY和EPM-1大鼠之间未观察到逃避潜伏期比率有显著差异。相反，与WKY和EPM-1大鼠相比，SHR的抑制性回避潜伏期显著缩短（平均±标准误潜伏期：SHR为65.9±18.4秒，WKY动物为129.9±2,1.8秒，EPM-1大鼠为181.2±11.2秒）。根据已知的与WKY和EPM-1大鼠相比SHR对厌恶环境的反应降低这一情况对这些数据进行了讨论。
