Childers M K, Rupright J, Smith D W
Department of Physical Medicine and Rehabilitation, University Hospital and Clinics, Columbia, MO 65212.
Brain Inj. 1994 May-Jun;8(4):335-43. doi: 10.3109/02699059409150984.
Fever frequently presents during recovery from traumatic brain injury (TBI). Elevated body temperature may result from ensuing infection, thrombophlebitis, drug reaction, or a defect in the central thermoregulatory system such as seen in post-traumatic hyperthermia (PTH). Typically, the diagnosis of PTH follows only after thorough investigation. Literature supports the theory that the febrile TBI patient, lacking a documented source, has central hyperthermia. The purpose of this study was to determine the incidence of PTH in the acute rehabilitation setting. We reviewed a consecutive series of 84 TBI patients participating in a rehabilitation programme. Four per cent of the patients in this study met our criteria for PTH. We describe a fever protocol that should aid the physician in diagnosis and treatment of the febrile TBI patient. Proposed mechanisms involved in thermoregulation are discussed.
发热在创伤性脑损伤（TBI）恢复期间经常出现。体温升高可能是由随后的感染、血栓性静脉炎、药物反应或中枢体温调节系统缺陷（如创伤后高热（PTH））引起的。通常，只有在进行全面调查后才能诊断出PTH。文献支持这样一种理论，即发热的TBI患者在没有记录到发热源的情况下，存在中枢性高热。本研究的目的是确定急性康复环境中PTH的发生率。我们回顾了连续参与康复计划的84例TBI患者。本研究中4%的患者符合我们的PTH标准。我们描述了一种发热治疗方案，该方案应有助于医生对发热的TBI患者进行诊断和治疗。文中还讨论了参与体温调节的可能机制。
