Smith R B, Tiberi A, Marshall J
Science and Clinical Services, MedTec 2000, Inc, Fort Worth, Texas.
Brain Inj. 1994 May-Jun;8(4):357-61. doi: 10.3109/02699059409150986.
This double-blind study sought to discover if cranial electrotherapy stimulation (CES), which is a known treatment of depression, anxiety and insomnia in non-head-injured patients, could be an effective, drug-free treatment of stress-related symptoms in the closed-head-injured (CHI) patient. In this study 10 CHI patients treated for 45 min daily, 4 days a week for 3 weeks, responded significantly on all negative mood factors of the Profile Of Mood States, while five sham-treated and six placebo controls did not. While the majority of the patients were known seizure cases, no patient suffered a seizure during CES therapy. No placebo effects were found, nor were any negative effects from CES treatment seen.
这项双盲研究旨在探究，对于非头部受伤患者而言，已知可治疗抑郁、焦虑和失眠的颅部电刺激疗法（CES），能否成为一种有效且无药物的疗法，用于治疗闭合性颅脑损伤（CHI）患者的应激相关症状。在本研究中，10名CHI患者每天接受45分钟治疗，每周治疗4天，持续3周，在情绪状态剖面图的所有负面情绪因素上均有显著反应，而5名接受假治疗的患者和6名安慰剂对照患者则无此反应。虽然大多数患者是已知的癫痫病例，但在CES治疗期间没有患者发作癫痫。未发现安慰剂效应，也未观察到CES治疗的任何负面影响。
