Wagner C, Braunger M, Beer M, Rother K, Hänsch G M
Institut für Immunologie, Universität Heidelberg, BRD.
Exp Nephrol. 1994 Jan-Feb;2(1):51-6.
Exposure of human glomerular mesangial cells (GMC) in culture to sublytic doses of the terminal complement proteins C5b-8 and C5b-9 caused a transient increase in abundance of mRNA specific for collagen type IV and fibronectin; mRNA of laminin was not affected. Since C5b-9 is found deposited in inflamed or sclerotic areas we propose that stimulation of matrix protein synthesis by C5b-9 might contribute to the development of glomerular sclerosis.
在培养过程中，将人肾小球系膜细胞（GMC）暴露于亚溶细胞剂量的终末补体蛋白C5b - 8和C5b - 9中，会导致IV型胶原和纤连蛋白特异性mRNA丰度短暂增加；层粘连蛋白的mRNA不受影响。由于在炎症或硬化区域发现有C5b - 9沉积，我们提出C5b - 9对基质蛋白合成的刺激可能有助于肾小球硬化的发展。
