Guo H, Wu G, Xu M
Institute of Military Medicine, Nanjing Command, PLA.
Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Feb;15(1):27-30.
Before 1986, tsutsugamushi disease was known only prevalent in south to Zhejiang Province in our country, belonged to the summer type and Leptotrombidium (L.) deliense was regarded as the main vector. In October 1986, the authors found this disease in Nanjing and carried out a series of studies in 1986-1992. The results were as follows: Tsutsugamushi disease was epidemic in Nanjing and north of Jiangsu (including: Dongtai, Haian, Rudong, Jinhu, Hanjiang, Jiangdu); belonged to the autumn-winter type; the main reservoir hosts were Apodemus agrarius, Rattus confucianus, R. norvegicus and Crocidura lasiura; the transmitting vector was L. (L.) scutellare; the pathogen of tsutsugamushi disease of the autumn-winter type-Rickettsia tsutsugamushi belonged to low-virulent strain, and could not easily be detected; after the inoculated mice were treated with diluted cyclophosphamide solution, 14 strains of R. tsutsugamushi have been isolated from rats, mites and patients; serological typing of their sera showed that they belonged to the Gilliam type; natural foci in Jiangsu could be divided into two types--flat land and hilly land.
1986年以前，恙虫病在我国仅知流行于浙江以南，属夏季型，地里纤恙螨被认为是主要传播媒介。1986年10月，作者在南京发现了此病，并于1986 - 1992年开展了一系列研究。结果如下：恙虫病在南京及江苏北部（包括：东台、海安、如东、金湖、邗江、江都）流行；属秋冬型；主要储存宿主为黑线姬鼠、褐家鼠、黄胸鼠和小麝鼩；传播媒介为小板纤恙螨；秋冬型恙虫病病原体——恙虫病立克次体属于低毒株，不易检出；用稀释的环磷酰胺溶液处理接种后的小鼠后，已从大鼠、螨和患者中分离出14株恙虫病立克次体；其血清学分型显示它们属于Gilliam型；江苏的自然疫源地可分为两种类型——平原和丘陵。
