State Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, China Centers for Disease Control and Prevention, Beijing 102206, China.
J Clin Microbiol. 2010 Apr;48(4):1241-4. doi: 10.1128/JCM.01784-09. Epub 2010 Feb 3.
Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.
恙虫病由恙虫东方体引起，最近在中国北方一些过去认为不存在恙虫病的地区出现。我们分析了 2008 年 9 月 26 日至 11 月 1 日期间在阜阳市一家医院住院的 104 例患者的流行病学、临床和实验室数据。我们发现，患者的主要临床表现为发热（100%）、头痛（82%）、肌痛（77%）、焦痂（67%）、皮疹（52%）和异常面部潮红（62%）。在 104 例患者中，98%的血清通过间接免疫荧光法（IFA）检测到对恙虫东方体的 IgM 抗体，36 例患者的血液中通过 PCR 扩增出恙虫东方体 56-kDa 基因的 DNA。我们得出结论，安徽省阜阳市的 104 例患者感染了恙虫病。我们的研究表明，过去认为不存在恙虫病的中国北方地区，发热患者的医生需要考虑恙虫病的诊断。
