Varinli S, Varinli I, Köksal Erkisi M, Doran F
Cukurova University Medical Faculty, Department of Pathology, Adana/Turkey.
Cent Afr J Med. 1994 Jan;40(1):24-6.
Between August 1991 and 1992 consecutive pterygium cases and eight normal conjunctival tissues were examined for the presence of polyclonal Human Papilloma Virus (HPV) antigen by the avidin-biotin-complex technique and 16 of the pterygium cases and 25 pc of the control conjunctivas revealed HPV positivity. In six of the HPV positive pterygium tissues, there were also an epithelial proliferation. In conclusion, HPV infection was not endemic, but sporadic in Cukurova region, and it may be contributed to development of pterygium. In addition, because it is seen together with six cases of epithelial hyperplasia, it seems to play an important role in the development of neoplasia and such patients need to be followed up for possible malignant transformation.
1991年8月至1992年期间，采用抗生物素蛋白-生物素复合物技术对连续性翼状胬肉病例和8份正常结膜组织进行多克隆人乳头瘤病毒（HPV）抗原检测，结果显示16例翼状胬肉病例和25%的对照结膜HPV呈阳性。在6例HPV阳性的翼状胬肉组织中，还存在上皮增生。总之，HPV感染在库库洛瓦地区并非地方性流行，而是散发性的，它可能与翼状胬肉的发生有关。此外，由于在6例上皮增生病例中同时发现了HPV，它似乎在肿瘤形成过程中起重要作用，这类患者需要进行随访以观察是否可能发生恶性转化。
