Mannhalter J W, Wolf H M, Hauber I, Miricka M, Gadner H, Eibl M M
Institute of Immunology, University of Vienna, Austria.
Clin Exp Immunol. 1994 Sep;97(3):392-5. doi: 10.1111/j.1365-2249.1994.tb06100.x.
The circulating T cell pool of an MHC class II-deficient patient was shown to lack the MHC class II-specific T cell functions. This was demonstrated by the absence of MHC class II-specific alloreactive T cells and a substantially decreased number of circulating CD4+ lymphocytes. The patient's T cells did respond to an allostimulus, although the restriction pattern of this reaction remains speculative. The function and distribution of peripheral T cell subsets from the patient resemble findings in MHC class II-deficient mice, which also lack interaction of T cell precursors with MHC class II-bearing accessory cells during thymic differentiation. Our data support the concept that T cell differentiation in humans is similar, and that the human MHC-restricted T cell repertoire depends on prior interaction of T cell precursors with self MHC.
一名MHC II类缺陷患者的循环T细胞库被证明缺乏MHC II类特异性T细胞功能。这通过缺乏MHC II类特异性同种异体反应性T细胞以及循环CD4 +淋巴细胞数量大幅减少得以证明。尽管该反应的限制模式仍具有推测性，但患者的T细胞确实对同种异体刺激有反应。该患者外周T细胞亚群的功能和分布类似于MHC II类缺陷小鼠的研究结果，后者在胸腺分化过程中也缺乏T细胞前体与携带MHC II类的辅助细胞的相互作用。我们的数据支持这样的概念，即人类T细胞分化是相似的，并且人类MHC限制的T细胞库取决于T细胞前体与自身MHC的先前相互作用。
