Schumacher U, Mukthar D, Schenker T
University of Southampton, U.K.
Dis Markers. 1993 Dec;11(5-6):225-37. doi: 10.1155/1993/619781.
A panel of monoclonal antibodies (n = 72 including controls) directed against lung cancer antigens was screened immunohistochemically against a panel of seven human lung cancer cell lines (including small cell carcinoma, squamous cell carcinoma, adenocarcinoma and mesothelioma), six human breast cancer cell lines and one human colon cancer cell line. The majority of the antibodies (n = 42) reacted also with antigens present on breast and colon cancer cell lines. This cross reactivity especially between lung and breast cancer cell lines is not altogether unexpected since antigens common to breast and lung tissue including their neoplasms such as MUC1 antigen have been described. Our results indicate that epitopes shared by lung and breast cancers are probably more common than previously thought. The relevance for prognosis and therapy of these shared antigens, especially as disease markers in breast cancer, has to be investigated.
一组针对肺癌抗原的单克隆抗体（共72种，包括对照抗体），采用免疫组织化学方法，对一组七种人肺癌细胞系（包括小细胞癌、鳞状细胞癌、腺癌和间皮瘤）、六种人乳腺癌细胞系和一种人结肠癌细胞系进行筛选。大多数抗体（42种）也与乳腺癌和结肠癌细胞系上存在的抗原发生反应。这种交叉反应，尤其是肺癌和乳腺癌细胞系之间的交叉反应，并不完全出乎意料，因为已经描述了乳腺和肺组织（包括其肿瘤）共有的抗原，如MUC1抗原。我们的结果表明，肺癌和乳腺癌共有的表位可能比以前认为的更为常见。这些共享抗原在预后和治疗方面的相关性，尤其是作为乳腺癌的疾病标志物，还有待研究。
