Wen H W, Liu S W
First School of Clinical Medicine, Beijing Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1994 Apr;29(4):235-7, 255.
From 1962 to 1989, 67 patients with stage I epithelial ovarian cancer were treated in our hospital. They were divided into three groups according to the time period of treatment. Thirteen patients treated in the 1960s were in group 1, 23 in the 1970s in group 2, and 31 in 1980s in group 3. There were no other significant differences other than the adjuvant chemotherapy in the three groups. In this study, the 5-year survival rate was 46% in group 1 (1962-1969), 82% in group 2 (1970-1979), and 97% in group 3 (1980-1989). The prognosis was improved significantly from 1960s to 1970s (P < 0.005), as well as from 1970s to 1980s (P < 0.05). Multivariate analysis indicated adjuvant chemotherapy (P < 0.01), stage (P < 0.01), and histological grade (P < 0.05) as having independent prognostic effects. Patients with more than 4 courses of combination chemotherapy, stage Ia, grade I and grade II had a better survival rate. The chemotherapy, complete surgical staging and preservation of fertility in surgical treatment of stage I epithelial ovarian cancer were also discussed.
1962年至1989年期间，我院共治疗了67例I期上皮性卵巢癌患者。根据治疗时间段将他们分为三组。20世纪60年代接受治疗的13例患者为第1组，20世纪70年代的23例为第2组，20世纪80年代的31例为第3组。三组之间除辅助化疗外无其他显著差异。本研究中，第1组（1962 - 1969年）的5年生存率为46%，第2组（1970 - 1979年）为82%，第3组（1980 - 1989年）为97%。从20世纪60年代到70年代（P < 0.005）以及从70年代到80年代（P < 0.05），预后均有显著改善。多因素分析表明辅助化疗（P < 0.01）、分期（P < 0.01）和组织学分级（P < 0.05）具有独立的预后影响。接受4个以上疗程联合化疗、Ia期、I级和II级的患者生存率更高。还讨论了I期上皮性卵巢癌手术治疗中的化疗、完整手术分期及生育功能保留问题。
