Lin C W, Orcutt M L, Stolbach L L
Cancer Res. 1975 Oct;35(10):2762-5.
Histaminase has been shown to be associated with several types of human cancer. In the present study, we examined the activity of histaminase and its relationship with Regan isoenzyme of alkaline phosphatase in ascitic fluids obtained from patients with ovarian and several other types of cancer. We have found that about 44% of the ovarian cancer patients had elevated levels of histaminase in the ascitic fluid, whereas a less frequent incidence was observed in fluids obtained from other types of cancer. There was concurrence in the elevation of histaminase activity with the appearance of Regan isoenzyme in most of the samples examined. Of the 10 patients who showed elevated histaminase, 9 had high Regan isoenzyme activity; whereas in 9 patients with normal levels of histaminase, all except 1 had low or moderate levels of Regan isoenzyme activity. These results, therefore, confirm the observation of an association of histaminase with human cancer and suggest the possibility for the utilization of histaminase, in conjunction with Regan isoenzyme and cancer-associated proteins, for cancer diagnosis and clinical evaluation of tumor progression and regression during therapy.
组胺酶已被证明与多种人类癌症相关。在本研究中，我们检测了从卵巢癌及其他几种癌症患者腹水中获取的组胺酶活性及其与碱性磷酸酶里甘同工酶的关系。我们发现，约44%的卵巢癌患者腹水中组胺酶水平升高，而在其他类型癌症患者的腹水中，这种情况的发生率较低。在大多数检测样本中，组胺酶活性升高与里甘同工酶的出现同时发生。在10名组胺酶水平升高的患者中，9名里甘同工酶活性较高；而在9名组胺酶水平正常的患者中，除1名外，其余患者里甘同工酶活性均为低或中等水平。因此，这些结果证实了组胺酶与人类癌症相关的观察结果，并表明组胺酶与里甘同工酶及癌症相关蛋白联合用于癌症诊断以及治疗期间肿瘤进展和消退的临床评估是有可能的。
