Strbák V, Dutour A, Nikodémová M, Oliver C
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
Horm Metab Res. 1994 Apr;26(4):173-4.
Pancreastatin (PST), a novel COOH-terminally alpha-amidated peptide is a part of Chromogranin A molecule. Precursor processing implies also the final amidation step dependent on peptidylglycine alpha-amidating monooxygenase (PAM). High activity of PAM as well as Thyroliberin (TRH, another alpha-amidated peptide) concentration and biosynthesis were reported to be very high in neonatal rat pancreas. We followed the concentration of PST-like immunoreactivity in rat pancreas during ontogenesis. High perinatal PST concentration, resembling that of previously reported for PAM activity and TRH concentration was found. These findings suggest that perinatal PAM activation may affect a broader spectrum of pancreatic peptides.
胰抑制素（PST）是一种新型的C末端α-酰胺化肽，是嗜铬粒蛋白A分子的一部分。前体加工还意味着最终的酰胺化步骤依赖于肽基甘氨酸α-酰胺化单加氧酶（PAM）。据报道，新生大鼠胰腺中PAM的高活性以及促甲状腺素释放激素（TRH，另一种α-酰胺化肽）的浓度和生物合成非常高。我们追踪了大鼠胰腺在个体发育过程中PST样免疫反应性的浓度。发现围产期PST浓度很高，类似于先前报道的PAM活性和TRH浓度。这些发现表明围产期PAM激活可能会影响更广泛的胰腺肽谱。
