细菌自杀的遗传控制：枯草芽孢杆菌中PBSX诱导的调控
Genetic control of bacterial suicide: regulation of the induction of PBSX in Bacillus subtilis.
作者信息
McDonnell G E, Wood H, Devine K M, McConnell D J
机构信息
Department of Genetics, Trinity College, Dublin, Ireland.
出版信息
J Bacteriol. 1994 Sep;176(18):5820-30. doi: 10.1128/jb.176.18.5820-5830.1994.
PBSX is a phage-like bacteriocin (phibacin) of Bacillus subtilis 168. Bacteria carrying the PBSX genome are induced by DNA-damaging agents to lyse and produce PBSX particles. The particles cannot propagate the PBSX genome. The particles produced by this suicidal response kill strains nonlysogenic for PBSX. A 5.2-kb region which controls the induction of PBSX has been sequenced. The genes identified include the previously identified repressor gene xre and a positive control factor gene, pcf. Pcf is similar to known sigma factors and acts at the late promoter PL, which has been located distal to pcf. The first two genes expressed from the late promoter show homology to genes encoding the subunits of phage terminases.
PBSX是枯草芽孢杆菌168产生的一种类噬菌体细菌素（噬菌素）。携带PBSX基因组的细菌受到DNA损伤剂诱导而裂解并产生PBSX颗粒。这些颗粒无法传播PBSX基因组。这种自杀反应产生的颗粒可杀死对PBSX不产生溶原性的菌株。一个控制PBSX诱导的5.2 kb区域已被测序。鉴定出的基因包括先前鉴定的阻遏基因xre和一个正调控因子基因pcf。Pcf与已知的σ因子相似，并作用于位于pcf远端的晚期启动子PL。从晚期启动子表达的前两个基因与编码噬菌体末端酶亚基的基因具有同源性。
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