Boedeker B H, Lojeski E W, Kline M D, Haynes D H
Department of Anesthesiology, Walter Reed Army Medical Center, Washington, DC 20307-5001.
J Clin Pharmacol. 1994 Jun;34(6):699-702. doi: 10.1002/j.1552-4604.1994.tb02026.x.
This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clamping after the installation of a subcutaneous ring block. Ten percent microencapsulated tetracaine was found to provide local anesthesia of the tail for a 43-hour duration. Ten percent tetracaine solution was toxic. One percent tetracaine solution provided a tail block lasting 8 hours. Lecithin membranes without drug provided no block. This study demonstrates that lecithin-coated tetracaine microcrystals produce a local anesthetic effect that is ultra-long in duration, reversible, and not systemically toxic.
本研究旨在确定微囊化丁卡因是否比未微囊化（纯）丁卡因能提供更长时间的局部麻醉。通过监测大鼠在皮下环形阻滞给药后对夹尾的反应来确定局部麻醉效果。发现10%的微囊化丁卡因可使尾部局部麻醉持续43小时。10%的丁卡因溶液有毒。1%的丁卡因溶液可使尾部阻滞持续8小时。不含药物的卵磷脂膜无阻滞作用。本研究表明，卵磷脂包被的丁卡因微晶产生的局部麻醉作用持续时间极长、可逆且无全身毒性。
