Mahony C, Spain C, Spain M, Evans J, Ferguson J, Smith M D
Division of Cardiology, University of Kentucky Medical Center, Lexington 40536-0084.
J Ultrasound Med. 1994 Jun;13(6):443-50. doi: 10.7863/jum.1994.13.6.443.
The purpose of this study was to determine why spontaneous contrast developed after general anesthesia in dogs. Twenty-seven dogs underwent echocardiography before and after pentobarbital or chloralose-urethane general anesthesia. The results showed that none of the 12 dogs receiving pentobarbital and 10 of 15 dogs receiving chloralose-urethane anesthesia developed contrast, in association with large platelet and platelet-neutrophil aggregates (P < 0.01); this effect could also be reproduced in vitro. The administration of adenosine diphosphate or antiplatelet antibody to nine dogs confirmed that intravascular platelet aggregation can cause ultrasonic contrast. The implications of these findings for patients with spontaneous contrast are discussed.
本研究的目的是确定犬全身麻醉后出现自发显影的原因。27只犬在戊巴比妥或氯醛糖 - 乌拉坦全身麻醉前后接受了超声心动图检查。结果显示，接受戊巴比妥的12只犬中无一出现显影，而接受氯醛糖 - 乌拉坦麻醉的15只犬中有10只出现显影，并伴有大量血小板及血小板 - 中性粒细胞聚集体（P < 0.01）；这种效应在体外也能重现。对9只犬给予二磷酸腺苷或抗血小板抗体证实，血管内血小板聚集可导致超声显影。本文讨论了这些发现对自发显影患者的意义。
