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[下肢闭塞性血栓性脉管炎的动脉内溶栓治疗]

[Intraarterial thrombolytic therapy in obliterative thromboangiitis of the lower extremities].

作者信息

Gervaziev V B, Kolobova O I

出版信息

Khirurgiia (Mosk). 1993 Feb(2):26-32.

PMID:8084146
Abstract

The article analyses the immediate and late-term results of treatment of patients suffering from thromboangiitis of the lower limbs with acute forms of thromboses of the main arteries and shunts (13 persons) and chronic arterial insufficiency (60 patients). The treatment consisted in intraarterial drug infusion with the use of fibrinolysis activators (celiasa, awelysin) as well as other pathogenetically aimed agents in the form of microcrystal suspensions (hydrocortisone, oxytetracycline, zinc insulin). Regional thrombolysis in acute thrombosis allowed authentic lysis of fresh thrombi in the main arteries in two patients (15%). Local thrombolysis with subsequent course of arterial infusion made possible effective arrest of the local ischemic syndrome in patients with III-IV degree arterial insufficiency and affection of the distal arterial bed and allowed the limb to be preserved during a follow-up period of 2 years in 92.5% of patients.

摘要

本文分析了患有下肢血栓性脉管炎并伴有主动脉和分流急性血栓形成(13例)以及慢性动脉供血不足(60例)患者的治疗近期和远期结果。治疗方法包括动脉内药物输注,使用纤溶激活剂(纤溶酶、阿韦利辛)以及其他具有病因学针对性的药物,以微晶悬浮液的形式(氢化可的松、土霉素、胰岛素锌)。急性血栓形成时的区域溶栓使两名患者(15%)主动脉内的新鲜血栓真正溶解。局部溶栓并随后进行动脉输注疗程,使得动脉供血不足III-IV度且远端动脉床受累的患者局部缺血综合征得到有效控制,并使92.5%的患者在2年随访期内保住了肢体。

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