Takeda Y
Nihon Naibunpi Gakkai Zasshi. 1975 Feb 20;51(2):85-97. doi: 10.1507/endocrine1927.51.2_85.
Changes in thyroid hormone levels and their relationship with TSH in cases with Hashimoto's thyroiditis and 131I treated Graves' disease in subclinical hypothyroid state were investigated: 1) In 34 cases with Hashimoto's thyroiditis, TSH levels was 14.7 +/- 26.8 muU/ml (mean +/- s.d.), T3 144.5 +/- 33.6 Rg/100 ml; T4 6.7 +/- 2.4 MUG/100 ML; T3RU 25.4 +/- 3.2%; F.T.I. 2.0g +/- O.89; T3/T4 2.46+/- 1.04%. It was noted that TSH levels revealed significant positive correlation with T3/T4 (r=0.77); significant inverse correlation with F.T.I. (r= - 0.51); and non-significant inverse correlation with T3 levels (r= - 0.06). These results indicate that T3 might play a more important role than T4 in maintaining normal thyroid function (so-called T3 euthyroidism). This is probably based on metabolic disturbance of iodine which is common in Hashimoto's thyroid. In several cases with rather high normal basal T3 levels, no significant elevation in T3 was observed in spite of elevated TSH level following TRH administration. This might indicate that the thyroid is fully functioning and that no more reserve is left for the thyroid to respond further to elevated TSH. 2) In 30 cases with 131I treated Graves' disease, TSH concentration was 22.3 +/- 29.8 muU/ml (mean +/- s.d.); T3 100.7 +/- 35.4 ng/100 ml: T4 6.2 +/- 2.9 MUG/100 ML; T3RU 25.6 +/- 2.3%; F.T.I. 1.87 +/- 0.85; T3/T4 1.80 +/- 0.64. Significant inverse correlation was noted between TSH levels and F.T.I. as well as T3 levels. Although TSH levels showed significant positive correlation with T3/T4 (r=0.44), its degree of correlation was not as good as that with F.T.I. (r= - 0.71) and T3 (r= - 0.53). These results indicate that there is no preference in T3 production. From the responsiveness of thyroid and pituitary following TRH administration, assumption can be drawn that 131I treated Graves' patients, who became euthyroid, may in fact be on the way to hypothyroidism.
研究了亚临床甲状腺功能减退状态下桥本甲状腺炎及¹³¹I治疗的格雷夫斯病患者甲状腺激素水平的变化及其与促甲状腺激素（TSH）的关系：1）34例桥本甲状腺炎患者，TSH水平为14.7±26.8μU/ml（均值±标准差），T3为144.5±33.6μg/100ml；T4为6.7±2.4μg/100ml；T3摄取率（T3RU）为25.4±3.2%；游离甲状腺指数（F.T.I.）为2.09±0.89；T3/T4为2.46±1.04%。注意到TSH水平与T3/T4呈显著正相关（r = 0.77）；与F.T.I.呈显著负相关（r = -0.51）；与T3水平呈非显著负相关（r = -0.06）。这些结果表明，在维持正常甲状腺功能（所谓的T3正常甲状腺功能状态）方面，T3可能比T4发挥更重要的作用。这可能基于桥本甲状腺中常见的碘代谢紊乱。在几例基础T3水平相当高且正常的病例中，尽管注射促甲状腺激素释放激素（TRH）后TSH水平升高，但未观察到T3有显著升高。这可能表明甲状腺功能已充分发挥，甲状腺对升高的TSH不再有更多的反应储备。2）30例¹³¹I治疗的格雷夫斯病患者，TSH浓度为22.3±29.8μU/ml（均值±标准差）；T3为100.7±35.4ng/100ml；T4为6.2±2.9μg/100ml；T3RU为25.6±2.3%；F.T.I.为1.87±0.85；T3/T4为1.80±0.64。注意到TSH水平与F.T.I.以及T3水平之间存在显著负相关。尽管TSH水平与T3/T呈显著正相关（r = 0.44），但其相关程度不如与F.T.I.（r = -0.71）和T3（r = -0.53）。这些结果表明，T3产生不存在偏好。从TRH给药后甲状腺和垂体的反应性可以推断，¹³¹I治疗后甲状腺功能恢复正常的格雷夫斯病患者实际上可能正处于甲状腺功能减退的过程中。
