Rutter J J, Gundlah C, Auerbach S B
Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855.
Neurosci Lett. 1994 Apr 25;171(1-2):183-6. doi: 10.1016/0304-3940(94)90635-1.
The effect of prolonged uptake inhibition with fluoxetine (10 mg/kg/day i.p. x 14 days) on extracellular serotonin (5-HT) in the rat diencephalon was monitored using in vivo microdialysis. The increase in extracellular 5-HT after repeated administration of fluoxetine was significantly greater than the increase produced by a single injection of this uptake blocker. This difference may have been due to a decrease in somatodendritic autoreceptor sensitivity, since the response to a low dose of the 5-HT1A agonist 8-OH-DPAT (25 micrograms/kg i.v.) was abolished in the chronic rats, while the response to a high dose (100 micrograms/kg i.v.) was attenuated as compared to animals injected once with fluoxetine.
采用体内微透析技术监测了氟西汀（10毫克/千克/天，腹腔注射，共14天）长期摄取抑制对大鼠间脑中细胞外5-羟色胺（5-HT）的影响。重复给予氟西汀后细胞外5-HT的增加显著大于单次注射这种摄取阻滞剂所产生的增加。这种差异可能是由于躯体树突状自身受体敏感性降低所致，因为慢性给药大鼠对低剂量5-HT1A激动剂8-羟基二丙胺四乙酸（8-OH-DPAT，25微克/千克，静脉注射）的反应消失，而与单次注射氟西汀的动物相比，对高剂量（100微克/千克，静脉注射）的反应减弱。
