Ciani E, Contestabile A
Department of Biology, University of Bologna, Italy.
Neurosci Lett. 1994 Apr 25;171(1-2):41-4. doi: 10.1016/0304-3940(94)90599-1.
The localization of calbindin neurons was studied in different brain areas of rats rendered microencephalic by gestational methylazoxymethanol acetate (MAM) treatment. In layers VI and V of the cortex, the only recognizable layers in MAM-treated rats, a higher density of calbindin interneurons and an apparent increase in protein expression was observed. In the hippocampus, calbindin pattern was essentially preserved, despite the dramatic decrease in size. In other telencephalic regions, calbindin distribution was not changed except for the septum, where a large increase of calbindin neurons was observed. The present results suggest that the MAM model may be used to investigate the role of calbindin.
通过孕期给予乙酸甲基氧化偶氮甲醇（MAM）处理使大鼠形成小头畸形，研究了不同脑区中钙结合蛋白神经元的定位。在MAM处理大鼠仅有的可识别皮层第VI层和第V层中，观察到钙结合蛋白中间神经元密度较高且蛋白表达明显增加。在海马体中，尽管体积显著减小，但钙结合蛋白模式基本保持不变。在其他端脑区域，除了隔区观察到钙结合蛋白神经元大量增加外，钙结合蛋白分布没有变化。目前的结果表明，MAM模型可用于研究钙结合蛋白的作用。
