Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno N
Department of Morphological Brain Science, Faculty of Medicine, Kyoto University, Japan.
Neurosci Lett. 1994 Apr 25;171(1-2):52-4. doi: 10.1016/0304-3940(94)90602-5.
Expression patterns of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7 mRNAs were quite different from that of mGluR6 mRNA which was expressed at the outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell bodies of the ganglion cells, but not in the inner or outer nuclear layer. The expression of mGluR7 mRNA was observed throughout the entire region of the inner nuclear layer and on the cell bodies of the ganglion cells.
通过Northern印迹分析和原位杂交组织化学方法，检测了大鼠视网膜中L-AP4敏感的代谢型谷氨酸受体（mGluR4、mGluR6、mGluR7）mRNA的表达模式。mGluR4和mGluR7 mRNA的表达模式与在内核层外部表达的mGluR6 mRNA的表达模式有很大不同。mGluR4 mRNA在神经节细胞的细胞体上表达，但在内核层或外核层中不表达。mGluR7 mRNA的表达在内核层的整个区域以及神经节细胞的细胞体上均有观察到。
