[Blood pressure and levels of catecholamines during physical exertion in patients with essential hypertension].

UNLABELLED

Material of the study consisted of 30 patients with borderline (BH) and 30 with (EH) established essential uncomplicated hypertension in age 18-50 years and 30 healthy men (N) in age 20-46 years. The patients did not receive treatment at least 14 days before the study. In all subjects the submaximal exercise ergometer test was performed. Blood pressure was measured in sitting position using mercury sphygmomanometer five times: before the test, in first and third minute of exercise, at the moment of submaximal exercise and after 30 minutes recovery. Blood samples were taken three times: before the test, at the moment of submaximal exercise and in 30th minute of recovery. Plasma concentrations of adrenaline and noradrenaline were assessed. In all groups significant increase was seen of systolic and diastolic blood pressure as well as plasma catecholamine concentrations at the maximal level of exercise in comparison to the basal values. The noradrenaline exercise concentrations was highest in patients with borderline hypertension. The adrenaline concentration was higher in hypertensive subjects than in controls. These differences were statistically significant. The degree of increase of noradrenaline during the test was significantly greater in patients with borderline hypertension than in other groups.

CONCLUSION

different catecholamines reaction on exercise in examined groups suggest the involvement of sympathetic system in pathogenesis of essential hypertension.