D'Souza L, Madaiah M, Day R A, Nickerson K W
Int J Pept Protein Res. 1975;7(3):251-9. doi: 10.1111/j.1399-3011.1975.tb02440.x.
Penicillinase (E.C. 3.5.2.6) from Bacillus cereus 569/H is inhibited by Hg(II). The inhibition is characterized by non-competitive kinetics and can be reversed by EDTA. A Hg(II) induced conformational change is indicated because: (1) The EDTA regenerated activity is unstable and is rapidly converted to an iodine-sensitive state, and (2) An irreversible change in the circular dichroism spectrum at 222 nm is found.
蜡样芽孢杆菌569/H产生的青霉素酶（E.C. 3.5.2.6）受到汞（II）的抑制。这种抑制作用表现为非竞争性动力学，并且可以被乙二胺四乙酸（EDTA）逆转。表明汞（II）诱导了构象变化，原因如下：（1）EDTA再生的活性不稳定，会迅速转变为对碘敏感的状态；（2）在222纳米处发现圆二色光谱发生了不可逆变化。
