Ambrosch F, Fritzell B, Gregor J, Jonas S, Kollaritsch H, Teulieres L, Wiedermann G
Institute for Specific Prophylaxis and Tropical Medicine, University of Vienna, Austria.
Vaccine. 1994 May;12(7):625-8. doi: 10.1016/0264-410x(94)90267-4.
In order to evaluate a combination of yellow fever and typhoid fever vaccine, we conducted a controlled trial comparing reactogenicity and immunogenicity of Vi polysaccharide (ViPS) vaccine and yellow fever 17D (YF) vaccine after single, simultaneous and combined administration. The combined YF/ViPS vaccine was prepared by using the liquid ViPS vaccine as a diluent for the YF vaccine. The stability of such a reconstitution had been assessed in vitro. Safety was evaluated using a self-surveillance form and by repeated clinical visits. Immunogenicity was evaluated by a plaque reduction test for YF and by radioimmunoassay for ViPS. Tolerability was satisfactory in all groups. There was no increase in local or general reactions in groups receiving both vaccines, whether given simultaneously or combined. The serological response to ViPS was similar after single and simultaneous or combined administration. Interestingly, the immune response to YF was significantly enhanced in groups receiving the vaccines simultaneously or combined, suggesting a potential adjuvant effect of ViPS.
为了评估黄热病和伤寒热疫苗的联合使用效果，我们进行了一项对照试验，比较了Vi多糖（ViPS）疫苗和黄热病17D（YF）疫苗在单次、同时和联合接种后的反应原性和免疫原性。联合使用的YF/ViPS疫苗是通过将液体ViPS疫苗用作YF疫苗的稀释剂制备的。这种重构的稳定性已在体外进行了评估。安全性通过自我监测表格和反复的临床访视进行评估。免疫原性通过YF的蚀斑减少试验和ViPS的放射免疫测定进行评估。所有组的耐受性均令人满意。接受两种疫苗的组，无论是同时接种还是联合接种，局部或全身反应均未增加。单次接种以及同时或联合接种后，对ViPS的血清学反应相似。有趣的是，在同时或联合接种疫苗的组中，对YF的免疫反应显著增强，这表明ViPS具有潜在的佐剂作用。
