Faussat J M, Roger G, Dautzenberg M D, Coste A, Maarek H, Manac'h Y
Service d'ORL et de chirurgie cervico-faciale, Hôpital Necker, Enfants Malades, Paris.
Ann Otolaryngol Chir Cervicofac. 1993;110(7):405-14.
Haemorrhages in the upper aero-digestive tract, whether spontaneous or provoked by surgery, lead to the discovery of abnormal coagulation. A retrospective series of 43 children hospitalized for haemorrhage of the upper aero-digestive tract enabled us to evaluate the most frequent causes. Willebrand's disease, haemophilia and Glanzmann's thromboasthenia, primary haemostasis disease, made up 27.9% of the cases; acquired impaired haemostasis by thrombopathies secondary to aspirin intake accounted for 25.6%; finally the haemostasis tests were normal in 46.5% of the children. Based on clinical features and biological data, we proposed an adapted diagnostic approach and discussed therapy in light of the current literature. This study confirmed the importance of an adapted routine battery of laboratory tests and the persistent search for impaired haemostasis in children hospitalized for haemorrhage of the upper aero-digestive tract.
上呼吸道消化道出血，无论是自发性的还是手术诱发的，都会导致发现凝血异常。一项对43名因上呼吸道消化道出血住院儿童的回顾性研究使我们能够评估最常见的病因。血管性血友病、血友病和血小板无力症等原发性止血疾病占病例的27.9%；因服用阿司匹林继发血栓形成性疾病导致的后天性止血功能受损占25.6%；最后，46.5%的儿童止血测试结果正常。基于临床特征和生物学数据，我们提出了一种适应性诊断方法，并根据当前文献讨论了治疗方法。这项研究证实了对上呼吸道消化道出血住院儿童进行适应性常规实验室检查以及持续寻找止血功能受损情况的重要性。
