[Semisynthetic penicillins: their importance in the current antibiotic therapy of infections. Penicillinase-resistant penicillins with predominantly antistaphylococcal action].

The status of isoxazolylpenicillins in the modern antibiotic therapy of staphylococcal infections is discussed from various viewpoints: the role and distribution of methicillin resistant staphylococci (MRSA), the methicillin tolerance, the clinical pharmacology and pharmacokinetics, the preferable administration routes and regimens depending on the disease severity and renal function, the prophylaxis of purulent infections, the indications to the combined therapy and possible side effects. It is indicated that one of the conditions providing the efficacy of penicillinase stable antistaphylococcal penicillins is the absolute knowledge of their properties and the joint efforts of the clinicians and bacteriologists in providing a rapid change of the drug after the detection of MRSA or methicillin tolerant staphylococci. This excludes any discredit of the drugs which are useful in the modern antistaphylococcal therapy.