Green J B
Miller Institute Fellow Department of Molecular & Cell Biology, University of California, Berkeley 94122.
Bioessays. 1994 Aug;16(8):539-40. doi: 10.1002/bies.950160806.
A recent article by Rao exemplifies a number of new trends in developmental biology, both of technical strategy and approach to the problem of neural induction. Rao introduced into frog embryos a mutant form of a mesodermal gene, Brachyury, and caused ectopic neural differentiation. This essay traces the route from the original Brachyury mutation in mouse to the most likely conclusion of Rao's experiments--suggested previously--that neural fate is a default pathway.
饶最近发表的一篇文章例证了发育生物学中的一些新趋势，涵盖技术策略以及解决神经诱导问题的方法。饶将一种中胚层基因Brachyury的突变形式导入青蛙胚胎，引发了异位神经分化。本文追溯了从最初小鼠中的Brachyury突变到饶的实验最可能得出的结论（此前已有人提出）——即神经命运是一种默认途径。
