Neurotoxicity of immunotoxins.
作者信息
Ilercil O, Laske D W, Walbridge S, Muaszko K, Oldfield E H, Youle R J
机构信息
Biochemistry Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
出版信息
Mol Chem Neuropathol. 1994 Feb-Apr;21(2-3):379-86. doi: 10.1007/BF02815363.
PMID:8086044
Abstract
Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.
摘要
Zotero 插件