卵巢癌中的杂合性缺失：通过聚合酶链反应和微卫星多态性进行检测
Loss of heterozygosity in ovarian cancer: detection by PCR and microsatellite polymorphism.
作者信息
Aguiari G L, Bianchi N, Cavazzini P, Martinello R, Lovato F, Mollica G, Piva R, del Senno L
机构信息
Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara.
出版信息
Boll Soc Ital Biol Sper. 1994 Apr;70(4):125-8.
Loss of chromosome 6q was investigated in endometrial and ovarian carcinomas by a PCR based-microsatellite polymorphism analysis. Results obtained show that this technique is able to detect frequent loss of heterozygosity in the ovarian cancers (10/27) and only in the serous type (8/17). Then, this kind of analysis can contribute to the understanding of tumor development and progression of ovarian cancers with different histopathological features.
通过基于聚合酶链反应（PCR）的微卫星多态性分析，对子宫内膜癌和卵巢癌中6号染色体长臂缺失情况进行了研究。所获结果表明，该技术能够检测出卵巢癌（27例中有10例）且仅在浆液性类型（17例中有8例）中存在频繁的杂合性缺失。因此，这种分析有助于理解具有不同组织病理学特征的卵巢癌的肿瘤发生和进展情况。
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