大鼠淀粉样蛋白前体样蛋白2（APLP2/APPH）的完整核苷酸序列和推导的氨基酸序列：与人类和小鼠同源物存在两个氨基酸长度差异。

Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues.

作者信息

Sandbrink R, Masters C L, Beyreuther K

机构信息

Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Germany.

出版信息

Biochim Biophys Acta. 1994 Sep 13;1219(1):167-70. doi: 10.1016/0167-4781(94)90263-1.

DOI:10.1016/0167-4781(94)90263-1

PMID:8086458

Abstract

We present the cDNA sequence of the rat amyloid precursor-like protein 2 (APLP2) comprising the complete coding sequence of 765 amino acid residues. By alternative splicing of two exons, transcripts encoding for 753, 709 and 697 amino acids are also generated. The derived amino acid sequence displays a sequence identity to human APLP2 of approx. 92% and to murine CDEI binding protein of approx. 95%, but differs from both by a deletion of 2 amino acids and an insertion of 4 amino acids within the acidic domain.

摘要

我们展示了大鼠淀粉样前体样蛋白2（APLP2）的cDNA序列，其包含由765个氨基酸残基组成的完整编码序列。通过两个外显子的可变剪接，还产生了编码753、709和697个氨基酸的转录本。推导的氨基酸序列与人类APLP2的序列同一性约为92%，与小鼠CDEI结合蛋白的序列同一性约为95%，但在酸性结构域内两者均有差异，分别缺失2个氨基酸和插入4个氨基酸。