Kameyama A, Maruta H, Minami K
Jpn J Antibiot. 1975 Aug;28(4):525-9.
Twenty-seven cases were treated with BB-K8, a new derivative of kanamycin acylated with l-(-)-gamma-amino-alpha-hydroxybutyric acid at the C-1 amino group of the 2-deoxystreptamine moiety. The majority of them were acute primary pyoderma and acute secondary pyoderma. BB-K8 was effective in 23 cases (85.2%) out of 27 cases treated and no side effect was encountered. BB-K8 had antibacterial activity against not only Staphylococcus but also Pseudomonas and Klebsiella. Thus, BB-K8 was considered to be effective in acute pyodermic condition.
27例患者接受了BB-K8治疗,它是卡那霉素的一种新衍生物,在2-脱氧链霉胺部分的C-1氨基上被L-(-)-γ-氨基-α-羟基丁酸酰化。其中大多数为急性原发性脓皮病和急性继发性脓皮病。在接受治疗的27例患者中,BB-K8在23例(85.2%)中有效,且未出现副作用。BB-K8不仅对葡萄球菌有抗菌活性,对假单胞菌和克雷伯菌也有抗菌活性。因此,BB-K8被认为对急性脓皮病有效。