Uva M G, Ott J P, Panta G, Randazzo D A, Reibaldi A
Institut für Augenheilkunde, Universität Catania.
Ophthalmologe. 1994 Jun;91(3):373-6.
The issue of whether silicone oil has a toxic effect on the retina is still being debated. In order to verify possible retinotoxic effects, the authors studied the variations of retinal function by means of computerized perimetry on patients who had undergone a vitreoretinal operation with injection of silicone oil in the vitreous cavity. Silicone oil remained in the eyes for a period of 120 days +/- 15.
14 patients under treatment for vitreoretinal pathologies sparing the macula underwent five examinations (Macular Threshold Test of the Humphrey Field analyzer): two examination during the period silicone oil was in the vitreous cavity (30 days after injection and 10 days before removal) and three examinations after its removal (at 30, 90, and 180 days).
When the paired t-test and ANOVA test were applied to our results, there were no significant differences in the light-difference sensitivity.
These data do not indicate that silicone oil a retinotoxic effect (revealed by means of computerized perimetry) when it is removed within 4 months.
硅油是否对视网膜有毒性作用这一问题仍在争论中。为了验证可能的视网膜毒性作用,作者通过计算机视野检查研究了在玻璃体腔注射硅油的玻璃体视网膜手术患者的视网膜功能变化。硅油在眼中留存120天±15天。
14例接受黄斑未受累的玻璃体视网膜病变治疗的患者接受了五次检查(Humphrey视野分析仪黄斑阈值测试):两次在硅油在玻璃体腔期间的检查(注射后30天和取出前10天)以及取出后三次检查(30天、90天和180天)。
当对我们的结果应用配对t检验和方差分析时,光差异敏感度无显著差异。
这些数据并未表明在4个月内取出时硅油具有视网膜毒性作用(通过计算机视野检查显示)。