Vylegzhanina T A, Kuznetsova T E, Maneeva O A, Novikov I I, Ryzhkovskaia E L
Med Tr Prom Ekol. 1993(9-10):6-8.
Daily doses of 50 mg/kg of lead acetate injected into the laboratory animals induce morphologic changes in the parenchyma of ovaries, thyroid gland, adrenals and compromises neural mediating processes in paraventricular and supraoptic nuclei of hypothalamus. The observed morphologic changes are similar to those characteristic for intensive functioning. Prolonged exposure to lead acetate (daily dose 10 mg/kg) results in adaptation and compensation, which preserves the functional potential of the organs. The morphologic changes in the endocrine organs do not lead to significant hormonal changes.
每天给实验动物注射50毫克/千克的醋酸铅会导致卵巢、甲状腺、肾上腺实质的形态学变化,并损害下丘脑室旁核和视上核的神经介导过程。观察到的形态学变化与高强度功能的特征相似。长期接触醋酸铅(每日剂量10毫克/千克)会导致适应和补偿,从而保留器官的功能潜力。内分泌器官的形态学变化不会导致显著的激素变化。