Trotter J
Department of Neurobiology, University of Heidelberg, Germany.
Perspect Dev Neurobiol. 1993;1(3):149-54.
The myelin-forming glial cells, oligodendrocytes and Schwann cells, undergo a sequence of maturation steps from precursor cell to mature myelinating cell. This includes migration from their site of generation to the axons they will myelinate. The recognition and interaction with the axons prior to the formation of compact myelin involve the interplay of a range of cell surface receptors and adhesion molecules, some of which have been defined. Signal transduction by such adhesion molecules may play a role in the recognition event. The generation of a range of immortalized cell lines and clones of oligodendroglial precursor cells and the analysis of their in vitro and in vivo properties have demonstrated the ability of these lines to recognize axons. They are providing useful tools to investigate the molecular basis of glia-neuron interactions.
形成髓鞘的神经胶质细胞，即少突胶质细胞和施万细胞，从前体细胞到成熟的髓鞘形成细胞要经历一系列成熟步骤。这包括从它们的产生部位迁移到它们将要形成髓鞘的轴突。在紧密髓鞘形成之前与轴突的识别和相互作用涉及一系列细胞表面受体和黏附分子的相互作用，其中一些已经明确。此类黏附分子的信号转导可能在识别事件中起作用。一系列少突胶质前体细胞的永生化细胞系和克隆的产生以及对它们体外和体内特性的分析，已经证明了这些细胞系识别轴突的能力。它们为研究神经胶质细胞与神经元相互作用的分子基础提供了有用的工具。
