Levine N S, Salisbury R E, Mason A D
Plast Reconstr Surg. 1975 Oct;56(4):423-9. doi: 10.1097/00006534-197510000-00009.
The effects of early and delayed surgical excision and skin homografting on survival in burned, uninfected rats and in burned rats infected with Pseudomonas aeruginosa, intraperitoneally, has been studied. The survival rate in animals treated with surgical excision and no coverage was significantly worse than in the animals who were simply burned. Immediate excision of the burn wound followed by prompt coverage with skin homografts resulted in decrease in the mortality rate from subsequent intraperitoneal infection of Pseudomonas. The beneficial effects of early surgical excisions and immediate skin homograft coverage were also achieved when formalin-fixed skin homografts were used.
研究了早期和延迟手术切除及皮肤同种异体移植对未感染的烧伤大鼠以及腹腔注射铜绿假单胞菌的感染烧伤大鼠存活率的影响。接受手术切除但未覆盖的动物的存活率显著低于单纯烧伤的动物。立即切除烧伤创面并迅速用皮肤同种异体移植物覆盖，可降低随后腹腔感染铜绿假单胞菌导致的死亡率。使用甲醛固定的皮肤同种异体移植物时，也能实现早期手术切除和立即皮肤同种异体移植覆盖的有益效果。
